Acne

First, the pathophysiology
   ↳ Sebaceous gland hyperactivity
                      ↓
      Change in Follicular Keratinization
                      ↓
      The influence of Bacteria
                      ↓
      Cutibacterium acnes (formerly Propionibacterium acnes)
                      ↓
                 gram(+)
                            ↳ which combine with TLR-2 in stimulating IL-6,
                               IL-12 causing inflammation.          

As treatment
  Normalizing Keratinization and Exfoliation
                      ↓
         Elimination or reducing Cutibacterium acnes
                      ↓
         Removing the molecule that clogs the pore
                      ↓
         Attacking the inflammatory response
                      ↓
         Decreasing the level of sebum secretion  
 
Biochemical Treatment – through anti-inflammation
 ↳ All-trans retinoic acid
    ↳lower Monocytes TLR-2 + CD-14
                    ↓
        inhibit the irritating of Cutibacterium acnes
                    ↓
            Produce pro-inflammatory hormone
 
※    Due to Acne has [MMP1, 3, 9]↑, causing scars.
       ↳ Retinoids will inhibit MMPs → to prevent scars.
 
After treatment
 ↳ We strongly recommend to clean your face properly and regulate the total microbiome
     on your face. 
     The Acne treatments always follow the rules – “An ounce of prevention is worth a pound cure”.
     Keep your face clean and maintain the microbiomes will be the best ways in helping your skin
     healthier. And of course, the best treatment is to go seeing a doctor.