Regulation Of Skin Ecology

Admin on Jul th, 2019

The number of studies aiming to analyze interactions between the skin and its microbiota has increased considerably in recent years, making this subject a scientific breakthrough.
Consumers have been informed and educated on the beneficial effects of bacteria and the importance of preserving this flora to maintain healthy skin
It is known that a finely regulated community, nutrition, and defense against aggression by pathogens.
The microbiota, therefore, has a pivotal role in the biology of organisms, whether in the plant or animal kingdom. Its equilibrium determines the development and maintenances of their hosts.
The relationship between aging and the cutaneous microbiota was studied by the use of meta sequencing to compare the microbiomes of young and old Caucasian skin.
A.      A significant decrease of the phylum Actinobacteria with an increase of Proteobacteria
B.      A significant increase of the genus Corynebacterium
How can we maintain skin health by using microorganism
1.      Prebiotic – feed bacteria
2.      Probiotic – add bacteria
3.      Postbiotic – use bacterial compounds
Due to law limited to skincare products, using probiotic ways as skincare products will be unavailable.
Furthermore, using the prebiotic method is another way in keeping the epidermis microbiome grow better, but the nutrition such as glucose and amino acid will cause both good and bad flora increasing.
Still, not the best methods.
Now, the best way is using the postbiotic compound as skin microbiome balance control.
For instance, Propionibacterium acnes, which keeps eating lipid as the nutrition source, but having them grow too fast, will cause acne and other problem 
There are several types of phylum will cause affection from the skin.
A. Actinobacteria (6 types)                           - TWEL
B. Bacteroidetes (6 types)                             - TWEL      
C. Firmicutes
D. Proteobacteria (7 types)                           - Lipid
E. Pityrosporum ; Malassezia furfur              - Immune
F. Propionibacterium acnes                          - Acnes
  = Cutibacterium acnes
G. Staphylococcus epidermidis                    - TWEL, Immune, Aging
H. Corynebacterium Kroppenstedtii            - Inflammation

The impact of age on the distribution of bacterial communities at the level of the six-major genera.

The result shows differences in the skin microbiota between young and old donors.
The abundance of old donors is significantly higher for the phylum Proteobacteria and the genus Corynebacterium, as well as a significantly lower abundance for the phylum Actinobacteria and the genus Propionibacterium, compared to the microbiota of young donor.

The abundance of the microbiota of old donors is higher for the phylum Proteobacteria and the genus Corynebacterium compared to the microbiota of young donors.
We rebalance the skin microbiota of old donors after 28 days by acting on the distribution of bacterial communities via a significant decrease of the abundance of the phylum Proteobacteria of 25% and the genus Corynebacterium of 23%.
The Cutibacterium acnes(also called Propionibacterium acnes) not only cause acne when it grows too fast but can eat lipid as controlling oil content, which shows how important the balance of microflora is.

RNase 7, in a model of artificial deterioration of the skin barrier.
It was shown that deterioration of skin barrier by stripping let to the rapid secretion of RNase 7, thereby forming a defensive shield to protect wounded skin from microbial colonization.
Ribonuclease 7 (RNase 7) is an antimicrobial protein expressed by human Keratinocytes to a substantial extent and that has a broad spectrum of antimicrobial action.
It plays a major role in defense of the skin: at high levels, it regulates the growth of Corynebacteria.
After 14 days of pre-treatment, we provide an emulsified gel that promotes the release of anti-microbial peptides, RNase 7, whose broad spectrum of activity contributes to the skin's system of defense.
We boost the secretion of RNase 7 by +119% (P=0.0072) after an artificial deterioration of the skin barrier. It is observed in 87% of volunteers.